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Dry Age-Related Macular Degeneration

Learning and Managing This Progressive Vision Loss Condition

UNDERSTANDING DRY MACULAR DEGENERATION

Dry AMD (Atrophic Age-Related Macular Degeneration) is a progressive condition affecting the central retina. Approximately 90% of all AMD cases are caused by the accumulation of drusen (extracellular deposits) beneath the retinal pigment epithelium (RPE). If left untreated, Dry AMD can lead to gradual vision loss and, ultimately, irreversible blindness.

Until now, early-stage AMD could only be managed with diet and supplements. Photobiomodulation (PBM) now offers a new way to help protect and possibly restore vision.

Representative imaging of macular drusen reduction following photobiomodulation treatment.

What is Photobiomodulation (PBM)?

Photobiomodulation is a light-based therapy that uses specific wavelengths of visible to near-infrared light (590, 660, and 850 nm) to stimulate cellular repair and reduce inflammation in retinal tissue.

PBM targets mitochondrial dysfunction, one of the known contributors to Dry AMD, while:

  • Improving cellular energy production (ATP)
  • Reducing oxidative stress
  • Stabilizing mitochondrial function
  • Activating signaling pathways for cell survival and regeneration


This unique approach helps improve retinal structure and function and may reduce the risk of geographic atrophy (GA) development.

Clinically-Proven Results

The LIGHTSITE III clinical trial evaluated multiwavelength PBM therapy in 100 patients across 10 centers. Participants received PBM treatment using the LumiThera Valeda Light Delivery System. After a 13-Month Analysis, it was discovered:

PBM-treated eyes showed an average gain of 5.4 letters in best-corrected visual acuity (BCVA), compared to 3.0 in the sham group.

55% of PBM eyes gained 5 or more letters; 26% gained 10 or more.

PBM-treated eyes had a significantly lower incidence of new-onset geographic atrophy (1.1% vs. 9.8%).

Anatomical imaging confirmed stabilization or reduction of drusen in PBM eyes.

No signs of phototoxicity; strong safety and compliance profile.

These outcomes demonstrate PBM’s potential as a disease-modifying treatment for early to intermediate Dry AMD.

Early intervention is key. The sooner AMD is detected, the better the chance of slowing or reversing damage. At Urban Optics, we offer advanced diagnostics and access to the latest non-invasive treatment options for retinal care. Contact us today to book your comprehensive macular evaluation and learn whether PBM therapy is appropriate for your eye health.

FAQ

Is PBM Right for Me?

You might be eligible for PBM Treatment if you:

  • Are 50+ years old
  • Have early or intermediate Dry AMD
  • Are not yet experiencing center-involving geographic atrophy
  • Want to take proactive steps to preserve or improve vision

Is PBM painful?

Photobiomodulation (PBM) is an entirely non-invasive treatment. It uses low-level light to gently stimulate retinal cells without any injections, incisions, or physical contact with the eye. Most patients find it comfortable and quick, with no downtime after each session.

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